Intra-cytoplasmic sperm injection (ISCI) is an assisted reproduction technique which consists of inseminating an egg by micro-injecting a sperm inside it after harvesting the eggs in the laboratory. The procedure is very similar to in vitro fertilisation (IVF) and only the insemination technique changes. Once the egg is fertilised it becomes a pre-embryo and is transferred into the uterus 2, 3, 5 or 6 days later so it can continue its normal development.
This technique is useful in cases of couples in which the male is sterile or has sperm anomalies (absence or low mobility, low concentration, altered sperm morphology or absence of sperm).
It is also used in cases of immunological sterility (anti-sperm antibodies).